منابع مشابه
Glomerular diseases: FSGS.
FSGS is a lesion, not a disease. The separation into primary FSGS (a result of immunologic-mediated injury) versus secondary FSGS (related to a variety of causes) is often difficult. Even when this particular issue is carefully evaluated, the therapeutic implications are not always apparent. Newer literature on both biomarker discovery and on the genetic basis of FSGS is reviewed in this contex...
متن کاملFSGS Recurrence in Adults after Renal Transplantation
Recurrence of focal segmental glomerulosclerosis (FSGS) in the allograft occurs in 30-50% of patients, and it is associated with poor renal allograft survival. Major risk factors for recurrence are younger age at diagnosis, rapid progression to end-stage renal disease, white race, and the loss of previous allografts due to recurrence. Recent data support the hypothesis that circulating permeabi...
متن کاملTreatment of primary FSGS in adults.
Over the last 20 years, primary FSGS has emerged as one of the leading causes of idiopathic nephrotic syndrome in adults, particularly among African Americans. In nephrotic patients, progression to ESRD often occurs over the course of 5-10 years, whereas non-nephrotic patients and those entering a remission have an extremely favorable prognosis. As a result, it is in patients who remain persist...
متن کاملFSGS: Diagnosis and Diagnostic Work-Up
Focal segmental glomerulosclerosis is a histologic lesion, rather than a clinical disease. FSGS is common cause of nephrotic syndrome in both adults and children worldwide. In the United States it is the most common primary glomerular disease resulting in end-stage renal disease and recent reports have suggested that its incidence might be on the rise. Currently the incidence is estimated to be...
متن کاملTreatment with Glucocorticoids or Calcineurin Inhibitors in Primary FSGS.
BACKGROUND AND OBJECTIVES In primary FSGS, calcineurin inhibitors have primarily been studied in patients deemed resistant to glucocorticoid therapy. Few data are available about their use early in the treatment of FSGS. We sought to estimate the association between choice of therapy and ESRD in primary FSGS. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We used an inception cohort of patient...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2017
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2017.42